INSECT AND - ANIMAL BORNE VIRAL INFECTIONS
EBOLA AND MARBURG VIRUS INFECTIONS
Ebola and Marburg viruses are related viruses that cause hemorrhagic fevers - diseases characterized by bleeding (hemorrhage), organ failure, and in many cases, death. Both Ebola and Marburg virus are in Africa, where outbreaks have occurred sporadically for decades. No human case of Ebola haemorrhagic fever have been reported in the United States. Ebola and Marburg live in one or more host animals and humans can contract the virus from infected animals. After the initial transmission, the virus can spread from person to person by contact with bodily fluids or contaminated needles. There is no effective treatment for hemorrhagic fever caused by Ebola and Marburg virus. People diagnosed with Marburg or Ebola virus receive supportive care and treatment of complications.
Virus causes Marburg hemorrhagic fever (MHF), also called the Marburg virus disease, and previously also known as green monkey disease because of its primate origins. Marburg Central and Eastern Europe, and infects humans and nonhuman primates. Marburg virus is the same taxonomic family, Ebola, and both are similar in structure, although it would different antibodies.
HISTORY
This virus has been documented in 1967 when 31 people became sick in the German city of Marburg ,after which it is named Frankfurt am Main and the then Yugoslav city of Belgrade. The outbreak involved 25 primary infections, with seven dead and six secondary cases, no deaths. The primary infections were in laboratory staff exposed to Marburg virus while working with monkeys or their tissues. The secondary cases involved two doctors, a nurse, a post-mortem worker, and married to a veterinarian. All were in direct contact, usually involving blood, with a primary case. Both doctors became infected through accidental skin pricks when drawing blood from patients.
TRANSMISSION
Disease spreads to body fluids such as blood, faeces, saliva and vomit. The first symptoms are often vague, and usually include fever, headache and muscle aches after the incubation period is 3-9 days. After five days, maculopapular rash is often present in the body. At a later stage of Marburg infection is acute and may have jaundice, pancreatitis, weight loss, delirium and neuropsychiatric symptoms, bleeding, hypovolemic shock and multi-organ failure, liver failure most common. offshore accounts to evade physical gaps are widespread popular references to the disease, but in fact rare. Now, of course, varies, but symptoms usually last from one to three weeks, to repair disease or kill the infected host. The mortality rate is 23% more than 90%....... read more
Ebola and Marburg viruses are related viruses that cause hemorrhagic fevers - diseases characterized by bleeding (hemorrhage), organ failure, and in many cases, death. Both Ebola and Marburg virus are in Africa, where outbreaks have occurred sporadically for decades. No human case of Ebola haemorrhagic fever have been reported in the United States. Ebola and Marburg live in one or more host animals and humans can contract the virus from infected animals. After the initial transmission, the virus can spread from person to person by contact with bodily fluids or contaminated needles. There is no effective treatment for hemorrhagic fever caused by Ebola and Marburg virus. People diagnosed with Marburg or Ebola virus receive supportive care and treatment of complications.
Virus causes Marburg hemorrhagic fever (MHF), also called the Marburg virus disease, and previously also known as green monkey disease because of its primate origins. Marburg Central and Eastern Europe, and infects humans and nonhuman primates. Marburg virus is the same taxonomic family, Ebola, and both are similar in structure, although it would different antibodies.
HISTORY
This virus has been documented in 1967 when 31 people became sick in the German city of Marburg ,after which it is named Frankfurt am Main and the then Yugoslav city of Belgrade. The outbreak involved 25 primary infections, with seven dead and six secondary cases, no deaths. The primary infections were in laboratory staff exposed to Marburg virus while working with monkeys or their tissues. The secondary cases involved two doctors, a nurse, a post-mortem worker, and married to a veterinarian. All were in direct contact, usually involving blood, with a primary case. Both doctors became infected through accidental skin pricks when drawing blood from patients.
TRANSMISSION
Disease spreads to body fluids such as blood, faeces, saliva and vomit. The first symptoms are often vague, and usually include fever, headache and muscle aches after the incubation period is 3-9 days. After five days, maculopapular rash is often present in the body. At a later stage of Marburg infection is acute and may have jaundice, pancreatitis, weight loss, delirium and neuropsychiatric symptoms, bleeding, hypovolemic shock and multi-organ failure, liver failure most common. offshore accounts to evade physical gaps are widespread popular references to the disease, but in fact rare. Now, of course, varies, but symptoms usually last from one to three weeks, to repair disease or kill the infected host. The mortality rate is 23% more than 90%....... read more
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PRECAUTIONARY MEASURES FOR TREATING PATIENT'S OF EBOLA AND MARBURG INFECTION |
Safety Study of Single Administration Post-Exposure Prophylaxis Treatment for Ebola Virus
ReplyDeletehttp://www.clinicaltrials.gov/ct2/show/NCT01353027?term=AVI+BIOPHARMA&rank=4
A similar trial with AVI-6003 to treat infection with the Marburg virus is being conducted at West Coast Clinical Trials in Cypress, California.
http://www.clinicaltrials.gov/ct2/show/NCT01353040?term=AVI+BIOPHARMA&rank=3
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