Showing posts with label ebola virus. Show all posts
Showing posts with label ebola virus. Show all posts

Thursday, April 28, 2011

Ebola virus

INSECT AND - ANIMAL BORNE VIRAL INFECTIONS
EBOLA AND MARBURG VIRUS INFECTIONS

Ebola and Marburg viruses are related viruses that cause hemorrhagic fevers - diseases characterized by bleeding (hemorrhage), organ failure, and in many cases, death. Both Ebola and Marburg virus are in Africa, where outbreaks have occurred sporadically for decades. No human case of Ebola haemorrhagic fever have been reported in the United States. Ebola and Marburg live in one or more host animals and humans can contract the virus from infected animals. After the initial transmission, the virus can spread from person to person by contact with bodily fluids or contaminated needles. There is no effective treatment for hemorrhagic fever caused by Ebola and Marburg virus. People diagnosed with Marburg or Ebola virus receive supportive care and treatment of complications.

Virus causes Marburg hemorrhagic fever (MHF), also called the Marburg virus disease, and previously also known as green monkey disease because of its primate origins. Marburg Central and Eastern Europe, and infects humans and nonhuman primates. Marburg virus is the same taxonomic family, Ebola, and both are similar in structure, although it would different antibodies.


HISTORY
This virus has been documented in 1967 when 31 people became sick in the German city of Marburg ,after which it is named  Frankfurt am Main and the then Yugoslav city of Belgrade. The outbreak involved 25 primary infections, with seven dead and six secondary cases, no deaths. The primary infections were in laboratory staff exposed to Marburg virus while working with monkeys or their tissues. The secondary cases involved two doctors, a nurse, a post-mortem worker, and married to a veterinarian. All were in direct contact, usually involving blood, with a primary case. Both doctors became infected through accidental skin pricks when drawing blood from patients.



TRANSMISSION
Disease spreads to body fluids such as blood, faeces, saliva and vomit. The first symptoms are often vague, and usually include fever, headache and muscle aches after the incubation period is 3-9 days. After five days, maculopapular rash is often present in the body. At a later stage of Marburg infection is acute and may have jaundice, pancreatitis, weight loss, delirium and neuropsychiatric symptoms, bleeding, hypovolemic shock and multi-organ failure, liver failure most common. offshore accounts to evade physical gaps are widespread popular references to the disease, but in fact rare. Now, of course, varies, but symptoms usually last from one to three weeks, to repair disease or kill the infected host. The mortality rate is 23% more than 90%....... read more


PRECAUTIONARY MEASURES FOR TREATING PATIENT'S OF EBOLA AND MARBURG INFECTION 

Ebola virus and marburg virus disease spread from person to person by contact


INSECT AND - ANIMAL BORNE VIRAL INFECTIONS 


EBOLA AND MARBURG VIRUS INFECTIONS 


CAUSES 
Marburg and Ebola virus has risen to tropical rainforests in Africa, in mid-20th century. Live virus animal host or reservoir's .People were probably infected when they invaded their habitats, and found a virus for the first time. Researchers Have identified a type of African fruit bat as a source of virus. Even if infected with Ebola and Marburg in contact with monkeys, chimpanzees and other nonhuman primates, these animals are not subject to natural virus. Instead, they are a ring of infection.

Once a person has been infected with Ebola or Marburg virus, the virus can spread to others through contact with bodily fluids that his person or through the use of contaminated needles or syringes. Investigators do not believe that humans produce enough Ebola or Marburg virus in droplets to cause infection through casual contact.


SIGN AND SYMPTOMS 
After the incubation period of 5-10 days, fever, muscle aches and headaches often occur abdominal symptoms (nausea, vomiting, pain, diarrhea), and upper respiratory symptoms (cough, chest pain, pharyngitis). Photophobia, conjunctival injection, jaundice and lymphadenopathy occur. Delirium, stupor and coma may occur, suggesting the involvement of the CNS. hemorrhagic symptoms begin within the first days and include petechiae, bruising, bleeding and Frank puncture sites and mucous membranes. Maculopapular rash, mainly in wood, from about 5 days.

During the second week of symptoms, or fever clearance occurs and patients begin to recover, or multiple organ failure patients develop fatal. The recovery is long and may be complicated by recurrent hepatitis, uveitis, transverse myelitis, and orchitis. Mortality ranges from 25-90% (higher Ebola).


DIAGNOSIS 
Ebola and Marburg hemorrhagic fever is difficult to diagnose because many of the early signs and symptoms resemble other infectious diseases such as typhoid and malaria. But if doctors suspect that you have been exposed to Ebola or Marburg virus, using laboratory tests to identify the virus in a few days. Most people with Ebola or Marburg haemorrhagic fever have high concentrations of virus in their blood. Blood tests known as enzyme-linked immunosorbent assay (ELISA) and reverse transcriptase chain reaction (PCR) can detect specific genes or viruses or antibodies against them.


TREATMENT 
No antiviral drug has proven effective in the treatment of infection with Ebola or Marburg virus. Consequently, treatment consists of medical support. This includes the provision of fluids to maintain adequate blood pressure to replace blood loss and treat all infections that develop. Some people receive transfusions of plasma to restore blood proteins to enhance coagulation. Public health officials urge hospitals to keep people with Ebola or Marburg haemorrhagic fever isolated from others in negative pressure rooms, which maintain the flow of air rather than enclosed spaces. Health workers should follow strict precautions for infection control.

COMPLICATIONS 
Both Ebola and Marburg hemorrhagic fever lead to death for a large percentage of people who suffer. As the disease progresses, it can cause multiple organ failure, severe bleeding, jaundice, delirium, convulsions, coma and shock. Death often occurs within 10 days after the onset of signs and symptoms. One reason why viruses are so deadly is that they interfere with the immune system's ability to defend itself. But scientists do not understand why some people recover from Ebola and Marburg and others not. For those who survive, recovery is slow. It can take months to regain weight and strength, and the virus remains in the body for several weeks. People may experience hair loss, sensory changes, hepatitis, weakness, fatigue, headache,  inflammation of eye , inflammation of the testicles........ read more